En la esclerosis sistémica, el esófago se afecta en un 90%, seguido de los tramos anorrectal (%), gástrico ( 70%), colon (%) e intestino delgado. La esclerodermia es un relativamente infrecuente enfermedad reumática autoinmunitaria que afecta la piel y otros órganos del cuerpo. La esclerosis sistémica es una enfermedad autoinmune del tejido conectivo, que se caracteriza por un depósito excesivo de tejido colágeno y otros.

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Tratamiento de la esclerosis sistémica | Reumatología Clínica

Arthritis Rheum, 43pp. Mol Immunol, 42pp. Surgical management of the hand in scleroderma. N Engl J Med,pp.

Controlled trial of nifedipine in the treatment of Raynaud’s phenomenon. Semin Arthritis Rheum, 35pp. Ann Pharmacother, 40pp. Left ventricular wall motion abnormalities sistemia 80 patients with systemic sclerosis. Rheumatology Oxford44pp.


J Rheumatol, 27pp. Drugs Exp Clin Res, 13pp. Prazosin treatment of Raynaud’s phenomenon: J Rheumatol, 29pp.

Nat Clin Pract Rheumatol, 2pp. J Rheumatol, 12pp.

Diagnosis of this disease is based on the observation of mucocutaneous telangiectasia, visceral lesions, epistaxis and first-grade family history. Cardiac and skeletal muscle disease in systemic sclerosis scleroderma: Bosentan therapy for pulmonary arterial hypertension.

Cardiac tamponade revealing systemic scleroderma. Once daily felodipine in patient with primary Raynaud’s phenomenon. Scleroderma complicated with tamponade during pregnancy. Dermatologic Therapy, 20pp.

Arthritis Rheum, 43pp. Joint Bone Spine, 72pp. A 50 year old male, with no relevant family history, who was diagnosed of subclinical hypothyroidism and early scleroderma has been follow-up by Rheumatology and Dermatology.

Bosentan therapy for cutaneous fibrosis in systemic sclerosis. The patient was referred to edclerosis Emergency ward of our hospital because of melena and epistaxis. Botulinum toxin in the treatment of Raynaud’s phenomenon: Severe refractory fingertip ulcerations in a patient with scleroderma: Angiology, 45pp.


Br J Rheumatol, 37pp. Effect of cold stress on coronary sinus blood flow in patients with scleroderma. Severe digital ischaemia treated with phosphodiesterase inhibitors. Br J Rheumatol, 32pp. Arthritis Rheum, 36pp.

Circulation,pp. Curr Opin Rheumatol, 11pp.

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Digital ulcers in systemic sclerosis. Curr Rheumatol Rep, 6pp. Comparable effects of sildenafil citrate and alprostadil on severe Raynaud’s phenomenon in a patient with systemic sclerosis. Cardiac valvular involvement is minor in systemic sclerosis; mitral valve is the sistemjca frequently affected. Am Heart J, 95pp. Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis. Arthritis Rheum, 44pp.