DOXIL PI PDF

DOXIL PI PDF

PI & CMI Trade Names and Active Ingredients containing doxorubicin. 7 Documents available Doxorubicin Ebewe, PI, Doxorubicin hydrochloride. Doxorubicin. Doxil official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Find information on drug affordability programs for DOXIL® (doxorubicin HCl liposome injection). Learn how patients who have been.

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Patients will have scheduled ddoxil with their healthcare provider while they are being treated with liposomal doxorubicin. All occurred during cycle 1 and none during subsequent cycles.

Los Angeles Cancer Network Doxil® – Los Angeles Cancer Network

This drug may cause birth defects. Doxil may damage spermatozoa and testicular tissue, resulting in possible genetic fetal abnormalities. By clicking “OK” below, you will be taken to a website that may contain links or references to other websites to which pl Privacy Policy may not apply.

The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. The following adverse reactions are discussed in more detail in other sections of the labeling.

Need help paying for your DOXIL® (doxorubicin HCl liposome injection) prescription?

In this trial, patients received Doxil for a median number of 3. And previous Grade 3 or 4 toxicity: At the current time, patient affordability programs for the selected insurance option are not available for this product.

Doxil, in combination with bortezomib, is indicated for the treatment doxik patients with multiple myeloma who have not previously received bortezomib and have received at least one prior therapy.

FDA alerts for all medications. Prior use of other anthracyclines or anthracenediones should be included in calculations of total cumulative dosage.

Independent co-pay assistance foundations Independent co-pay assistance foundations have their own rules for eligibility. Medicare Savings Program Many states have programs for people with limited income doixl resources that pay some or all of Medicare’s premiums and may pay Medicare deductibles and co-insurance.

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Two percent of patients developed signs and symptoms of congestive heart failure without documented evidence of cardiotoxicity. Inform patients that following Doxil administration, a reddish-orange color to the urine and other body fluids dodil be observed. Liposomal doxorubicin belongs to a group of agents called anthracycline antitumor antibiotics. The median survival was 33 months in the Doxil and bortezomib combination therapy group and 31 months in the bortezomib monotherapy group.

Print this page Add to My Med List. For neuropathic pain or peripheral neuropathy, no dosage adjustments are required for Doxil. You may be eligible for one or more of the following programs:. Painless ulcers, erythema, or mild soreness If no previous Grade 3 or 4 toxicity: Efficacy results are as shown in Table 13 and Figure 1.

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Blistering, ulceration, or swelling interfering with walking or normal daily activities; cannot wear regular clothing. HFS or other skin toxicity required discontinuation of Doxil in 4.

Clinical studies of Doxil conducted in patients with either epithelial ovarian cancer Trial 4 or with AIDS-related Kaposi’s sarcoma Trial 5 did not contain sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger subjects.

The use of the information on this site is subject to the terms of our Legal Notice and Privacy Policy. And no previous Grade 3 or 4 stomatitis: In animal reproduction studies, Doxil was embryotoxic in rats and abortifacient in rabbits following intravenous administration during organogenesis at doses approximately 0.

Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates on other clinical trials and may not reflect the rates observed in clinical practice. We comply with the HONcode standard for trustworthy health information – verify here. Refer to bortezomib manufacturer’s prescribing information.

TGA eBS – Product and Consumer Medicine Information

Advise pregnant women of the potential risk to a fetus. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice.

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A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug.

Some patients may experience reactions during administration of liposomal doxorubicin. Are there any special precautions patients should be aware of before starting treatment? State-Sponsored Programs Some states sponsor prescription financial assistance programs, each with its own eligibility requirements. This site is intended doxli the use of patients and caregivers in the United States.

The baseline demographics and clinical characteristics of the patients with multiple myeloma were similar between treatment arms Table If you do not have the package insert for the drug you odxil using, your pharmacist or physician may be able to provide you with a copy.

Acute Lymphoblastic Leukemia GleevecSprycelmethotrexateimatinibdoxorubicinmercaptopurineMore Demographics of the population were: If after 2 weeks there is no resolution, discontinue Doxil. Serious, life-threatening and fatal infusion reactions have been reported [see Dosage and Administration 2. Do not administer foxil an undiluted suspension or as an intravenous bolus [see Warnings and Precautions 5. What is a package insert? Mutagenicity or carcinogenicity studies have not been conducted with Doxil, however doxorubicin doxol shown to be mutagenic in the in vitro Ames assay, and clastogenic in multiple in vitro assays CHO cell, V79 hamster cell, human lymphoblast, and SCE assays and the in vivo mouse micronucleus assay.

Also, patients may want to talk to their physician if they are considering having children dodil the future, since some drugs may cause fertility problems.